kinase suppressor of Ras 2; hKSR2 (KSR2)

Function

• location-regulated scaffold connecting MEK to RAF
• blocks MAP3K8 kinase activity & MAP3K8-mediated signaling
• negative regulator of MAP3K3-mediated activation of ERK, JNK & NF-kappa-B pathways
• inhibits MAP3K3-mediated expression of IL-8
• interacts with MAP2K1, MAP3K8, MAPK, RAS & RAF
• phosphorylated on Ser-474 by MARK3 (putative)

Structure

• the protein kinase domain is predicted to be catalytically inactive
• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family
• contains 1 phorbol-ester/DAG-type Zn+2 finger
• contains 1 protein kinase domain

Compartment

• cytoplasm (putative), membrane
• peripheral membrane protein (putative)

Alternative splicing

named isoforms=2

Expression

mainly expressed in brain & kidney

More general terms

• phosphoprotein
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=283455
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:283455
• OMIM: https://mirror.omim.org/entry/610737
• UniProt: http://www.uniprot.org/uniprot/Q6VAB6.html