growth arrest & DNA-damage-inducible proteins-interacting protein 1 (CR6-interacting factor 1, CRIF1, CK2 beta-associating protein, papillomavirus L2-interacting nuclear protein 1, PLINP-1, GADD45GIP1, PLINP1)

Function

• negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases
• inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins
• cells overexpressing GADD45GIP1 were more likely to be in G1 & less likely to be in S phase & grow more slowly than control cells
• inhibiting the expression of GADD45GIP1 promotes cell cycle progression
• repressor of orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity
• role in hormone-mediated regulation of NR4A1 transcriptional activity (putative)
• interacts with GADD45A, GADD45B & GADD45G
• interacts with NR4A1 via the NR4A1 AB domain
• interacts with human papilloma virus type 16 (HPV 16) minor capsid protein L2

Compartment

nucleus

Expression

• widely expressed
• expressed in thyroid gland, heart, lymph nodes, trachea & adrenal tissues > liver skeletal muscle, kidney, pancreas, testis, ovary & stomach

Pathology

• barely detectable in
  • adrenal adenoma
  • papillary thyroid cancer

More general terms

• nuclear protein

Additional terms

• growth arrest & DNA-damage inducible-45 (GADD45)

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TAE8.html