nuclear receptor subfamily 4 group A member 1; early response protein NAK1; nuclear hormone receptor NUR/77; nur77; orphan nuclear receptor HMR; orphan nuclear receptor TR3; ST-59; testicular receptor 3 (NR4A1, GFRP1, HMR, NAK1)

Function

• orphan nuclear receptor
• interacts with GADD45GIP1
• can interact with DNA as monomer, forms heterodimer with RXR which binds to similar response elements as RAR-RXR

Structure

• belongs to the nuclear hormone receptor family, NR4 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus

Expression

• fetal muscle & adult liver, brain & thyroid
• induced by growth-stimulating agents

More general terms

• nuclear hormone receptor NR4 subfamily
• zinc finger protein
• DNA-binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P22736.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3164
• OMIM: https://mirror.omim.org/entry/139139