growth arrest & DNA-damage-inducible protein GADD45 beta; myeloid differentiation primary response protein MyD118; negative growth regulatory protein MyD118 (GADD45B, MYD118)

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Function

role in the regulation of growth & apoptosis
mediates activation of stress-responsive MTK1/MEKK4 MAPKKK
GADD45A, GADD45B & GADD45G bind to N-terminal domain of Mtk1 & activate Mtk1 kinase activity
interacts with GADD45GIP1

Structure

belongs to the GADD45 family

More general terms

growth arrest & DNA-damage inducible-45 (GADD45)

References

↑ UniProt http://www.uniprot.org/uniprot/O75293.html
↑ NIEHS-SNPs http://egp.gs.washington.edu/data/gadd45b/
↑ Takekawa M & Saito H A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95:521-30, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9827804

Database

Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4616
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4616
OMIM: https://mirror.omim.org/entry/604948
UniProt: http://www.uniprot.org/uniprot/O75293.html

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