growth arrest & DNA-damage-inducible protein GADD45 gamma; cytokine-responsive protein CR6; DNA-damage-inducible transcript 2; DDIT-2 (GADD45G CR6 DDIT2)

Function

• role in the regulation of growth & apoptosis
• mediates activation of stress-responsive MTK1/MEKK4 MAPKKK interacts with GADD45GIP1
• GADD45A, GADD45B & GADD45G bind to N-terminal domain of Mtk1 & activate Mtk1 kinase activity.

Structure

belongs to the GADD45 family

More general terms

• growth arrest & DNA-damage inducible-45 (GADD45)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10912
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10912
• OMIM: https://mirror.omim.org/entry/604949
• UniProt: http://www.uniprot.org/uniprot/O95257.html