cyclin-dependent kinase-12 (CDK12); Cdc2-related kinase, arginine/serine-rich; CrkRS; cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; cell division protein kinase 12; hCDK12 (CRK7, CRKRS, KIAA0904)

Function

• cyclin-dependent kinase
• displays CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thus acting as a regulator of transcription elongation.
• required for RNA splicing, possibly by phosphorylating SRSF1/SF2
• role in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors
• interacts with CCNL1 & CCNL2 (putative)

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
• contains 1 protein kinase domain

Compartment

• nucleus. nuclear speckle
• colocalized with nuclear speckles throughout interphase

Alternative splicing

named isoforms=3

Expression

ubiquitously expressed

Pathology

• chromosomal deletion within 17q12 region involving CDK12 producing fusion transcripts with ERBB2 may be a cause of gastric cancer
• deletion leads to CDK12-ERBB2 fusion with truncated CDK12 protein not in-frame with ERBB2

More general terms

• cyclin-dependent kinase (CDK)
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51755
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51755
• UniProt: http://www.uniprot.org/uniprot/Q9NYV4.html