chromosomal deletion 17q12 (gastric cancer)
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Introduction
- chromosomal deletion within 17q12 region involving CDK12 producing fusion transcripts with ERBB2 may be a cause of gastric cancer
- deletion leads to CDK12-ERBB2 fusion with truncated CDK12 protein not in-frame with ERBB2
More general terms
Additional terms
- cyclin-dependent kinase-12 (CDK12); Cdc2-related kinase, arginine/serine-rich; CrkRS; cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; cell division protein kinase 12; hCDK12 (CRK7, CRKRS, KIAA0904)
- receptor tyrosine-protein kinase erbB-2; p185erbB2; C-erbB-2; NEU proto-oncogene; tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 (ERBB2, HER2, NEU, NGL)