DNA repair protein XRCC3; X-ray repair cross-complementing protein 3 (XRCC3)

Function

• role in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations & deletions
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with RAD51C & RAD51. part of a complex
• consisting of RAD51B, RAD51C, RAD51D, XRCC2 & XRCC3

Structure

belongs to the recA family, RAD51 subfamily

Compartment

nucleus (probable)

Pathology

• Met-241 is associated with the development of cutaneous malignant melanoma

More general terms

• nuclear protein
• phosphoprotein

Component of

• BCDX2 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7517
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7517
• OMIM: https://mirror.omim.org/entry/600675
• UniProt: http://www.uniprot.org/uniprot/O43542.html