DNA repair protein XRCC2; X-ray repair cross-complementing protein 2 (XRCC2)

Function

• role in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations & deletions
• the BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA & specifically to nicks in duplex DNA
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with RAD51D
• part of a BCDX2 complex
• part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 & XRCC3
• in the absence of DNA, XRCC2-RAD51D forms a multimeric ring structure
• in the presence of single-stranded DNA, XRCC2-RAD51D forms a filamentous structure

Structure

belongs to the recA family, RAD51 subfamily

Compartment

nucleus

More general terms

• nuclear protein
• phosphoprotein

Component of

• BCDX2 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7516
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7516
• OMIM: https://mirror.omim.org/entry/600375
• UniProt: http://www.uniprot.org/uniprot/O43543.html