MyoD family inhibitor domain-containing protein (I-mfa domain- containing protein, HIC) (MDFIC)
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Function
- modulates the expression from both cellular & viral promoters
- down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat & Rev & impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta
- stimulates activation of human T-cell leukemia virus type 1 (HTLV-1) LTR
- binds to the axin complex, resulting in an increase in the level of free beta-catenin
- affects axin regulation of the WNT & JNK signaling pathways
- C-terminus interacts with HIV-1 Tat & Rev, AXIN1, the histidine-rich region of CCNT1/CYCLIN T & weakly with LEF1
Structure
- belongs to the MDFI family
- cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm
Compartment
- cytoplasm, nucleus, nucleolus
- isoform 1 localizes to the nucleolus & also shows a granular distribution in cytoplasm
- isoform 2 is predominantly distributed throughout cytoplasm, with only weak expression in nucleus
Alternative splicing
named isoforms=2
Expression
- expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes),prostate, uterus & small intestine
Notes
initiates from GTG codon