heart & neural crest derivatives-expressed protein 2 (deciduum, heart, autonomic nervous system & neural crest derivatives-expressed protein 2; dHAND; HAND2)

Function

• cardiac morphogenesis, especially formation of right ventricle & of aortic arch arteries
• vascular development & regulation of angiogenesis, viA VEGF signaling (putative)
• role in limb development, especially anterior-posterior polarization
• upstream regulator of sonic hedgehog induction in the limb bud
• development of branchial arches
• binds DNA on E-box consensus sequence 5'-CANNTG-3'
  • efficient DNA binding requires dimerization with another bHLH protein
  • homodimers & heterodimers with TCF3 gene products E12 & E47, HAND1 & HEY1, HEY2 & HEYL

Structure

• contains 1 basic helix-loop-helix (bHLH) domain

Expression

heart, fetal heart

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/602407
• UniProt: http://www.uniprot.org/uniprot/P61296.html