IKK-epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; I kappa-B kinase epsilon; IkBKE; IKK-E; inducible I kappa-B kinase; IKK-i (IKBKE, IKKE, IKKI, KIAA0151)
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Function
- part of a PMA-inducible IkB kinase complex distinct from the one containing IKK-alpha, IKK-beta & IKK-gamma
- IKKe phosphorylates Ser-36 but not Ser-32 of IkB alpha
- involved in PMA & T cell receptor induction of NF kappa B but not TNF-alpha or interleukin-1
- role in the immune response (putative)
- may interact with MAVS/IPS1
- interacts with AZI2
- interacts with SIKE
- interacts with TICAM1/TRIF, IRF3 & DDX58/RIG-I; interactions are disrupted by the interaction between IKBKE & SIKE
- autophosphorylated
Structure
- belongs to the protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily
- contains 1 protein kinase domain
Compartment
cytoplasm (probable)
Expression
- highly expressed in spleen > thymus, peripheral blood leukocytes, pancreas, placenta
- weakly expressed in lung, kidney, prostate, ovary & colon
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q14164.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/ikbke/
- ↑ Peters RT et al IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. Molecular Cell 5:513-22, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10882136