5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase- associated protein 1, Nak-associated protein 1, TILP, AZI2, NAP1)

Function

• activates serine/threonine protein kinase TBK1 & facilitates its oligomerization
• enhances phosphorylation of NF-kappa-B p65 subunit RELA by TBK1
• promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B
• participates in IFN-beta promoter activation via TICAM1
• interacts with IKBKE, TBK1 & TICAM1

Compartment

cytoplasm

Alternative splicing

named isoforms=3

Expression

• widely expressed
• abundant expression seen in pancreas & testis

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H6S1.html