Suppressor of IKK-epsilon (SIKE, SIKE1)
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Function
- physiological suppressor of IKK-epsilon & TBK1
- inhibitory role in virus- & TLR3-triggered IRF3
- inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) & the IFN-beta promoter
- may act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 & DDX58/RIG-I
- does not inhibit NF-kappa-B activation pathways
- interacts with IKBKE & TBK1 via its coiled coil region
- interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure
belongs to the SIKE family
Compartment
Alternative splicing
named isoforms=2
Expression
- widely expressed
- expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung & leukocytes
- present in all cell lines tested (at protein level)