zinc finger protein 741; Krueppel-like factor 8; basic Krueppel-like factor 3 (KLF8, BKLF3, ZNF741)

Function

• transcriptional repressor & transcriptional activator
• binds to CACCC-box promoter elements
• also binds the GT-box of cyclin D1 promoter
  • mediates cell cycle progression at G1 phase as a downstream target of focal adhesion kinase (FAK)
• sumoylation at Lys-67
  • represses transcriptional activity & reduces cell cycle progression into the G1 phase
  • no effect on subcellular location
• interacts with corepressor CtBP2
• interacts with PIAS1, PIAS2, & PIAS4;
  • interaction with each ligase sumoylates KLF8

Structure

• belongs to the Sp1 C2H2-type Zn+2-finger protein family
• contains 3 C2H2-type Zn+2 fingers

Compartment

nucleus

Expression

ubiquitous

More general terms

• Krueppel-like factor
• C2H2 type zinc finger protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11279
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11279
• OMIM: https://mirror.omim.org/entry/300286
• UniProt: http://www.uniprot.org/uniprot/O95600.html