BCL-6 corepressor (BCoR, KIAA1575)

Function

• transcriptional corepressor.
• inhibits gene expression when recruited to promoter regions by sequence specific DNA-binding proteins, including BCL6 & MLLT3
• associates with histone deacetylase
• isoform 1 interacts with MLLT3/AF9
• interacts with BCL6, HDAC1, HDAC3, HDAC5

Structure

• contains 3 ANK repeats

Compartment

nucleus

Alternative splicing

named isoforms=4

Expression

ubiquitously expressed

Pathology

• defects in BCOR are a cause of microphthalmia with associated anomalies 2

More general terms

• transcriptional silencer (transcriptional repressor)

Database

• OMIM: https://mirror.omim.org/entry/300412
• OMIM: https://mirror.omim.org/entry/300485
• UniProt: http://www.uniprot.org/uniprot/Q6W2J9.html