P2X7 purinoceptor; P2X purinoceptor 7; P2X7; ligand-gated ion channel purinergic receptor P2X7; P2Z receptor (P2RX7)

Function

• receptor for ATP
• acts as a ligand gated ion channel
• role in ATP-dependent lysis of macrophages via formation of membrane pores permeable to large molecules
• may function in both fast synaptic transmission & ATP-mediated lysis of antigen-presenting cells
• interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 & PTPRB
• phosphorylation results in its inactivation

Structure

• belongs to the P2X receptor family
• forms homo- or heteropolymers

Compartment

membrane

More general terms

• transmembrane 2 protein
• P2X purinoceptor or P2X purinergic receptor
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5027
• OMIM: https://mirror.omim.org/entry/602566
• UniProt: http://www.uniprot.org/uniprot/Q99572.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5027