receptor-type tyrosine-protein phosphatase beta; protein-tyrosine phosphatase beta; R-PTP-beta; vascular endothelial protein tyrosine phosphatase; VE-PTP (PTPRB, PTPB)

Function

• plays an important role in blood vessel remodeling & angiogenesis
• not necessary for the initial formation of blood vessels, but is essential for their maintenance & remodeling
• can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin & KDR/VEGFR-2
• regulates angiopoietin-TIE2 signaling in endothelial cells
• acts as a negative regulator of TIE2, & controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development & determines blood vessel size during perinatal growth
• essential for the maintenance of endothelial cell contact integrity & for the adhesive function of VE-cadherin in <A19311>endothelial cells</A19311> & this requires the presence of plakoglobin (putative)
• interacts with TEK
• interacts via fibronectin type-III 17 domain with CDH5 (putative)

protein tyrosine phosphate + H2O = protein tyrosine + phosphate

Structure

• monomer
• belongs to the protein-tyrosine phosphatase family receptor class 3 subfamily
• contains 17 fibronectin F3 modules
• contains 1 tyrosine-protein phosphatase domain

Compartment

• membrane; single-pass type 1 membrane protein (putative)

Alternative splicing

named isoforms=3

Expression

up-regulated by hypoxia

More general terms

• tyrosine phosphatase, receptor type
• plasma membrane protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5787
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5787
• OMIM: https://mirror.omim.org/entry/176882
• UniProt: http://www.uniprot.org/uniprot/P23467.html