laminin alpha-3 (nicein-alpha, kalinin-alpha, BM600, epiligrin 170 kD subunit, E170, laminin A3, LAMA3, LAMNA)

Function

• subunit of laminin-5
• subunit of laminin-6
• subunit of laminin-7

Structure

• alpha-helical domains I & II are thought to interact with other laminin chains to form a coiled coil structure
• domain G is globular
• contains 3 laminin EGF-like domains
• contains 5 laminin G-like domains

Compartment

• secreted, extracellular space, extracellular matrix
• basement membrane, major component

Alternative splicing

named isoforms=2

Expression

• skin; respiratory, urinary, & digestive epithelia & in other specialized tissues with prominent secretory or protective functions
• epithelial basement membrane, & epithelial cell tongue that migrates into a wound bed
• a differential & focal expression of laminin alpha-3 is observed in the CNS
• up-regulated in wound sites of human skin

Pathology

• defects in LAMA3 are a cause of
  • epidermolysis bullosa junctional Herlitz type
  • laryngoonychocutaneous syndrome

More general terms

• laminin-alpha (laminin A)

Component of

• laminin-5

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3909
• OMIM: https://mirror.omim.org/entry/226700
• OMIM: https://mirror.omim.org/entry/245660
• OMIM: https://mirror.omim.org/entry/600805
• UniProt: http://www.uniprot.org/uniprot/Q16787.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3909