hypoxia up-regulated protein 1; 150 kD oxygen-regulated protein; orp150 (HYOU1, ORP150)

Function

• role in cytoprotective cellular mechanisms triggered by oxygen deprivation
  • may play a role as a molecular chaperone & participate in protein folding
  • part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 & very small amounts of ERP29, but not, or at very low levels, CALR nor CANX

Structure

belongs to the heat shock protein 70 family

Compartment

endoplasmic reticulum lumen

Expression

• highly expressed in tissues that contain well-developed endoplasmic reticulum & synthesize large amounts of secretory proteins
  • highly expressed in liver & pancreas
  • lower expression in brain & kidney
  • induced by hypoxia, 2-deoxyglucose, tunicamycin

Pathology

• expressed in macrophages within atherosclerotic plaques of the aorta
• expressed in breast cancers

More general terms

• heat shock protein [hsp]-70 family

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10525
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10525
• OMIM: https://mirror.omim.org/entry/601746
• UniProt: http://www.uniprot.org/uniprot/Q9Y4L1.html