zinc finger protein 238; 58 kD repressor protein; transcriptional repressor RP58; translin-associated zinc finger protein 1; TAZ-1; zinc finger & BTB domain-containing protein 18; zinc finger protein C2H2-171 (ZNF238, RP58, TAZ1, ZBTB18)

Function

• transcriptional repressor
• role in developmental processes such as myogenesis & brain development
• role in myogenesis by directly repressing expression of ID2 & ID3, 2 inhibitors of skeletal myogenesis
• also involved in controlling cell division of progenitor cells & regulating survival of postmitotic cortical neurons
• specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, & acts by recruiting chromatin remodeling multiprotein complexes
• may also play a role in the organization of chromosomes in the nucleus
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with DNMT3A

Structure

• contains 1 BTB/POZ domain
• contains 4 C2H2-type Zn+2 fingers

Compartment

• nucleus
• associates with condensed chromatin

Alternative splicing

named isoforms=2

Expression

• expressed in lymphoid tissues, testis, heart, brain, skeletal muscle, pancreas >> other tissues

More general terms

• transcriptional silencer (transcriptional repressor)
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10472
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10472
• OMIM: https://mirror.omim.org/entry/608433
• UniProt: http://www.uniprot.org/uniprot/Q99592.html