neuroepithelial cell-transforming gene 1 protein; proto-oncogene p65 Net1; Rho guanine nucleotide exchange factor 8 (NET1, ARHGEF8)

Function

• guanine nucleotide exchange factor (GEF) for RhoA GTPase
• activation of the SAPK/JNK pathway
• interacts with RHOA in GTP- & GDP-bound states
• interacts with CDC42 in GTP-bound state
• interacts with the PDZ 1 domain of BAIAP1

Structure

• contains 1 DH (DBL-homology) domain
• contains 1 PH domain

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=2

Expression

• widely expressed
• induction by TGF-beta

More general terms

• rho guanine nucleotide exchange factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10276
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10276
• OMIM: https://mirror.omim.org/entry/606450
• UniProt: http://www.uniprot.org/uniprot/Q7Z628.html