Rho guanine nucleotide exchange factor 7; beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85 (ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314)

Function

• acts as a RAC1 guanine nucleotide exchange factor (GEF)
• can induce membrane ruffling
• may function as a positive regulator of apoptosis
• may function in cell migration
• downstream of NMDA receptors & CaMKK-CaMK1 signaling, promotes formation of spines & synapses in hippocampal neurons
• phosphorylated on Ser-694 by CaMK1
  • enhancement of GEF activity & downstream activation of RAC1
• interacts with PAK kinases through the SH3 domain
• interacts with GIT1 & TGFB1I1
• interacts with ITCH
• interacts with unphosphorylated PAK1
• interaction with SCRIB may play a role in regulation of apoptosis
• interacts with FRMPD4 (via N-terminus)
• interacts with CaMK1

Structure

• contains 1 CH (calponin-homology) domain
• contains 1 DH (DBL-homology) domain
• contains 1 PH domain
• contains 1 SH3 domain

Alternative splicing

named isoforms=6

More general terms

• rho guanine nucleotide exchange factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8874
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8874
• OMIM: https://mirror.omim.org/entry/605477
• UniProt: http://www.uniprot.org/uniprot/Q14155.html