KIN, antigenic determinant of recA protein homolog (protein KIN homolog, binding to curved DNA, KIN, BTCD, KIN17)

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Function

Structure

  • contains 1 C2H2-type zinc finger
  • C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to SH3-like domains both subdomains adopt a similar 5-stranded beta-barrel-like fold & are connected to each other by a short linker of 5 residues the 5 beta-sheets (folds) are packed at approximately right angles against each other a highly conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302 & 391 & other positively charged residues, may possibly be the site of RNA-binding

Compartment

Expression

Pathology

  • recognized by antibodies directed against the RecA protein
  • differentially expressed in non-tumorigenic & tumorigenic cell lines

More general terms

References

Database