DiGeorge syndrome critical region 8; microprocessor complex subunit DGCR8 (DGCR8, C22orf12, DGCRK6, LP4941)

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Function

Cofactor:

  • binds 1 heme group per homodimer

Structure

  • both DRBM domains are required for efficient binding to pri-miRNA
  • the region between residues 276 & 498 has an autoinhibitory function on pri-miRNA processing activity
  • contains 2 DRBM (double-stranded RNA-binding) domains
  • contains 1 WW domain

Compartment

Alternative splicing

named isoforms=3

Expression

ubiquitously expressed

More general terms

Additional terms

Component of

References

Database