microprocessor complex; pri-miRNA processing protein complex

Function

• involved in the initial step of microRNA (miRNA) biogenesis
• required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus

Structure

• DGCR8 (heme-free or heme-bound forms)
• DROSHA
• may contain multiple subunits of DGCR8 & DROSHA

Compartment

nucleus

More general terms

• molecular complex