ribonuclease inhibitor; ribonuclease/angiogenin inhibitor 1; RAI; placental ribonuclease inhibitor; Rnase inhibitor; RI (RNH1, PRI, RNH)

Function

• inhibitor of pancreatic Rnase & angiogenin
• may also function in the modulation of cellular activities
• forms a tight one-to-one complex with the Rnase

Structure

• the N-terminus is blocked
• contains 15 LRR repeats (leucine-rich repeats); protein built almost entirely of leucine-rich repeats
• at least 30 of the 32 Cys are in the reduced formCompartment: cytoplasm

More general terms

• phosphoprotein
• leucine-rich repeat-containing protein (LRRC)
• enzyme inhibitor

Component of

• dextromethorphan/guaifenesin/ribonuclease/angiogenin inhibitor
• aluminum hydroxide/magnesium hydroxide/ribonuclease/angiogenin inhibitor/simethicone

Database

• UniProt: http://www.uniprot.org/uniprot/P13489.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6050
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6050
• OMIM: https://mirror.omim.org/entry/173320