angiogenin; ribonuclease 5; Rnase 5 (ANG, RNASE5)
Jump to navigation
Jump to search
Function
- potent mediator of new blood vessel formation
- may function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs
- binds to actin on the surface of endothelial cells
- once bound, angiogenin is endocytosed & translocated to the nucleus
- angiogenin induces vascularization of normal & malignant tissues
- angiogenic activity is regulated by interaction with RNH1 in vivo
- interacts with & forms a tight 1:1 complex with RNH1
- dimerization of ANG/RNH1 heterodimer may occur
Structure
- belongs to the pancreatic ribonuclease family
Compartment
Expression
- mRNA expressed in wide spectrum of cells
- expressed predominantly in the liver
- also detected in endothelial cells & spinal cord neurons
- low level expression in the developing fetus,
- increased expression in the neonate
- maximal expression in the adult
Pathology
- defects in ANG are the cause of susceptibility to familial amyotrophic lateral sclerosis type 9
Laboratory
Notes
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P03950.html
- ↑ R&D systems' cytokine mini-reviews: angiogenin http://www.rndsystems.com/molecule_detail.aspx?m=1054
- ↑ Functional glycomics gateway - glycan binding http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_other_803
- ↑ GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/ANG
- ↑ OMIM https://mirror.omim.org/entry/105850
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=283