growth factor receptor-bound protein 14; GRB14 adapter protein (GRB14)

Function

• adapter protein that modulates coupling of cell surface receptor tyrosine kinases with specific signaling pathways
• binds to, & suppresses signals from, the activated insulin receptor (INSR)
• markedly decreases insulin-stimulated AKT1 phosphorylation
• potent inhibitor of insulin-stimulated MAPK3 phosphorylation
• phosphorylated on Ser
• interacts with the cytoplasmic domain of the autophosphorylated insulin receptor, through the SH2 domain
• binds to the ankyrin repeat region of TNKS2 via its N-terminus
• interacts with activated NRAS

Structure

• the PH domain binds relatively non-specifically & with low affinity to several phosphoinositides
  • strongest binding to PI(3,4,5)P3
• belongs to the GRB7/10/14 family
• contains 1 PH domain
• contains 1 Ras-associating domain
• contains 1 SH2 domain

Compartment

• cytoplasm
• Golgi membrane
• peripheral membrane
• endosome membrane
• upon insulin stimulation, translocates to the plasma membrane

Expression

• expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart, skeletal muscle

More general terms

• growth factor receptor-bound protein (GRB GRB adapter protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2888
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2888
• OMIM: https://mirror.omim.org/entry/601524
• UniProt: http://www.uniprot.org/uniprot/Q14449.html