growth factor receptor-bound protein 7; GRB7 adapter protein; epidermal growth factor receptor GRB-7; B47 (GRB7)

Function

• inhibits EGF receptor
• interacts with the cytoplasmic domain of EGFR via SH2 domain, inhibits it
• binds to ERBB2
• interacts with RND1
• phosphorylated on Tyr

Structure

homologous to ras-GAP

Alternative splicing

named isoforms=1

More general terms

• growth factor receptor-bound protein (GRB GRB adapter protein)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2886
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2886
• OMIM: https://mirror.omim.org/entry/601522
• UniProt: http://www.uniprot.org/uniprot/Q14451.html