dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)

Function

• role in the regulation of cellular growth &/or development
• regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM
• inactivates GYS1 by phosphorylation at Ser-641, & potentially also a second phosphorylation site, thus regulating glycogen synthesis
• phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation & inhibition by GSK3, & may play a more general role in the priming of GSK3 substrates
• autophosphorylates on Tyr
• phosphorylated on Ser/Thr (putative)

Cofactor: Mg+2, Mn+2

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily
• contains 1 protein kinase domain

Compartment

• cytoplasm. nucleus
• translocates into the nucleus following DNA damage

Alternative splicing

named isoforms=2

Expression

• testis, after the onset of spermatogenesis

More general terms

• dual-specificity tyrosine-phosphorylation regulated kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8445
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8445
• OMIM: https://mirror.omim.org/entry/603496
• UniProt: http://www.uniprot.org/uniprot/Q92630.html