dendritic cell-specific transmembrane protein; DC-STAMP; hDC-STAMP; dendrocyte-expressed seven transmembrane protein; IL-four-induced protein; FIND; transmembrane 7 superfamily member 4 (DCSTAMP, TM7SF4)

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Function

probable cell surface receptor
roles in
- cellular fusion
  - cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts & foreign body giant cells
- cell differentiation
  - role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage
  - inhibits differentiation of neutrophils
- bone homeostasis
  - role in TNFSF11-mediated osteoclastogenesis
  - participates in osteoclast bone resorption
  - role in inducing expression of tartrate-resistant acid phosphatase in osteoclast precursors
- immune homeostasis
  - role in regulation of dendritic cell antigen presentation by controlling phagocytic activity
  - role in maintenance of immune self-tolerance & avoidance of autoimmune reactions
isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 1 (via the C-terminus tail)
- the interaction induces DCSTAMP redistribution to the endoplasmic reticulum-Golgi intermediate compartment
isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 2 (via the C-terminus tail) (putative)
interacts with CREB3

glycosylated (putative)
monomer. homodimer
several domains are necessary for interacting with OS9
the region in the cytoplasmic tail that is necessary for interaction with OS9, is also required for its transport

cell membrane
endoplasmic reticulum membrane
endoplasmic reticulum-Golgi intermediate compartment membrane
localizes to the cell surface in osteoclasts & undifferentiated monocytes
intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor
colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cells
translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of dendritic cells (OS9-dependent)
colocalizes with LAMP1 in endosomes (putative)

expressed in lymph nodes, lung, kidney, liver > pancreas, bone marrow, spleen, leukocytes
preferentially expressed by dendritic cells, in both immature & mature dendritic cells
expression is down-regulated by dexamethasone & up-regulated by IL-4
down-regulated in CD40 ligand activated dendritic cells