lysosome-associated membrane glycoprotein 1; LAMP-1; CD107 antigen-like family member A; CD107a (LAMP1)

Function

• presents carbohydrate ligands to selectins

Structure

• O- & N-glycosylated
• some of the 18 N-linked glycans are polylactosaminoglycans
• belongs to the LAMP family

Compartment

• cell membrane, endosome membrane, lysosome membrane
• shuttles between lysosomes, endosomes, & the plasma membrane

Expression

• lysosomes
• degranulated platelets
• activated neutrophils
• T cells
• endothelium

Pathology

• may play a role in tumor metastasis

More general terms

• lysosome-associated membrane glycoprotein (LAMP)
• CD antigen

Database

• UniProt: http://www.uniprot.org/uniprot/P11279.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3916
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3916
• OMIM: https://mirror.omim.org/entry/153330