cyclic AMP-responsive element-binding protein 3; Luman protein; transcription factor LZIP-alpha (CREB3, LZIP)

Function

• binds to & requires HCFC1 as a coactivator
• activity & expression are suppressed when HCFC1-CREB3 complex binds ZF
• LKN-1 induced chemotaxis signaling
• interacts with CCR1, HCFC1, HCV core protein

Structure

N-glycosylated

Compartment

• endoplasmic reticulum
• upon activation, proteolysis cleaves N-terminal cytoplasmic domain (40 kD) that translocates into the nucleus

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• cAMP-responsive element [CRE]-binding protein (CREB)

Database

• OMIM: https://mirror.omim.org/entry/606443
• UniProt: http://www.uniprot.org/uniprot/O43889.html