centaurin-delta-2; Arf-GAP with Rho-GAP domain, ANK repeat & PH domain-containing protein 1; Cnt-d2 (ARAP1, CENTD2, KIAA0782)

Function

• phosphatidylinositol-3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF & RHO family members
• activated by phosphatidylinositol-3,4,5-trisphosphate (Ptdins(3,4,5)P3) binding
• can be activated by phosphatidylinositol-3,4-bisphosphate (Ptdins(3,4)P2) binding, albeit with lower efficiency
• has a preference for ARF1 & ARF5 (putative)
• interacts with TNFRSF10A

Structure

• contains 1 Arf-GAP domain
• contains 4 PH domains
• contains 1 Ras-associating domain
• contains 1 Rho-GAP domain
• contains 1 SAM (sterile alpha motif) domain

Compartment

• cytoplasm. Golgi, Golgi stack membrane;
• plasma membrane
• associated with Golgi stacks in resting cells
• throughout the cytoplasm & in surface protrusion in cells that are in the process of attaching to a surface & spreading

Alternative splicing

named isoforms=6

Expression

• detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid & trachea

More general terms

• centaurin delta
• phosphoprotein

Additional terms

• pleckstrin homology [PH] domain
• pleckstrin; platelet p47 protein (PLEK P47)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=116985
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:116985
• OMIM: https://mirror.omim.org/entry/606646
• UniProt: http://www.uniprot.org/uniprot/Q96P48.html