interleukin-12 receptor beta-2 chain; IL-12 receptor beta-2; IL-12R-beta2 (IL12RB2)

Function

• with I12RB1, forms functional high affinity IL12 receptor
• signaling component coupling to the JAK2/STAT4 pathway
• promotes the proliferation of T-cells as well as NK cells
• induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production
• Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain
• interaction, in vitro & in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation
• binds STAT4 through a membrane-distal C-terminal region
• on IL12 binding, phosphorylated on C-terminal Tyr by JAK2
• phosphorylation on Tyr-800 is required for STAT4 binding & activation, & for SOCS3 binding

Structure

• the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell-surface receptor binding
• the box 1 motif is required for JAK interaction &/or activation
• belongs to the type I cytokine receptor family, type 2 subfamily
• contains 5 fibronectin F3 modules

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• isoform 2 is expressed at similar levels in both naive & activated T-cells
• maximum levels in Th1 cells between day 3 & day 8 of activation
• in vitro, up-regulated by interferon alpha

Polymorphism

• heterozygotic variants Gly-313 & Arg-720 are associated with atopy

More general terms

• membrane protein
• protein subunit
• glycoprotein

Component of

• interleukin-12 receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3595
• OMIM: https://mirror.omim.org/entry/601642
• UniProt: http://www.uniprot.org/uniprot/Q99665.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3595