zinc finger protein 202; zinc finger protein with KRAB & SCAN domains 10 (ZNF202, ZKSCAN10)

Function

• transcriptional repressor
• binds to elements found predominantly in genes that participate in lipid metabolism
• among its targets are
  • structural components of lipoprotein particles (apolipoproteins apoA4, apoC3, & apoE)
  • enzymes involved in lipid processing
    • lipoprotein lipase
    • lecithin-cholesteryl ester transferase
  • transporters involved in lipid homeostasis (ABCA1, ABCG1)
  • several genes involved in processes related to energy metabolism & vascular disease
• interacts with SDP1

Structure

• contains 8 C2H2-type Zn+2 fingers
• contains 1 KRAB domain
• contains 1 SCAN box domain

Compartment

nucleus

Alternative splicing

• named isoforms=2; alpha

Expression

• highly expressed in testis

Pathology

• also expressed in breast carcinoma cell lines

More general terms

• transcriptional silencer (transcriptional repressor)
• C2H2 type zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7753
• OMIM: https://mirror.omim.org/entry/603430
• UniProt: http://www.uniprot.org/uniprot/O95125.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7753