ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; White protein homolog (ABCG1 ABC8, WHT1)
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Function
- transporter involved in macrophage lipid homeostasis
- active component of the macrophage lipid export complex
- role in intracellular lipid transport processes
- role in cellular lipid homeostasis may not be limited to macrophages
- may form heterodimers with several heterologous partners of the ABCG subfamily
Structure
- belongs to the ABC transporter family, ABCG (White) subfamily
- contains 1 ABC transporter domain
Compartment
- endoplasmic reticulum membrane
- Golgi membrane
- predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) & Golgi membranes
Alternative splicing
named isoforms=8
Additional isoforms seem to exist
Expression
- expressed in several tissues
- strongly induced in monocyte-derived macrophages during cholesterol influx
- conversely, mRNA & protein expression are suppressed by lipid efflux
- induction is mediated by the LXR/RXR pathway
- not induced by bacterial lipopolysaccharides (LPS)
- repressed by ZNF202
- highly induced in lipid-laden macrophages.
Pathology
- overexpressed in macrophages from patients with Tangier disease compared to control macrophages
- expressed in foamy macrophages within atherosclerotic plaques
- role in cholesterol metabolism of macrophages in vitro & in atherosclerotic plaques
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P45844.html
- ↑ Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):507-12. Epub 2001 Jan 9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11149950