ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ATP-binding cassette 1; ABC-1; cholesterol efflux regulatory protein (ABCA1, ABC1, CERP)

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Function

Structure

Compartment

membrane (putative)

Expression

Pathology

Genetics

Pharmacology

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/O95477.html SHMPD; The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ABCA1
  2. Laffitte BA et al, LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. PNAS 98:507, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11149950
  3. 3.0 3.1 3.2 Husten L, Fairchild DG, Di Francesco L HDL Function, Not Level, Looks Like the Key Physician's First Watch, Nov 19, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
    Rohatgi A et al HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events. N Engl J Med. Nov 18, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25404125 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1409065
  4. 4.0 4.1 4.2 Nordestgaard LT, Tybjaerg-Hansen A, Nordestgaard BG et al Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease. Alzheimers Dement. 2015 Dec;11(12):1430-8 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26079414
  5. 5.0 5.1 University of Arizona Health Sciences. Cholesterol may be key to new therapies for Alzheimer's disease, diabetes. ScienceDaily, 25 March 2021 https://www.sciencedaily.com/releases/2021/03/210325150226.htm
    Aissa MB, Lewandowski CT, Ratia KM et al Discovery of Nonlipogenic ABCA1 Inducing Compounds with Potential in Alzheimer's Disease and Type 2 Diabetes. ACS Pharmacology & Translational Science, 2021; 4 (1): 143 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33615168 PMCID: PMC7887740

Database