sentinel lymph node procedure

^[1]^[2]^[3]^[4]^[5]

Indications

* patients with early-stage ER-positive breast cancer with clinically node-negative axilla can forego sentinel lymph node biopsy^[4]

injection of blue dye or technetium-99m with gamma-probe localization allows a minimally invasive technique for detecting melanoma (or other cancer) metastases to local lymph nodes
the nodes are then resected (intact) & checked for cancer
radiation therapy may be directed at the site of the surgery & to nearby lymph nodes to destroy any remaining cancer cells

↑ Color Atlas & Synopsis of Clinical Dermatology, Common & Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY, 1997, pg 978
↑ ^{Jump up to: 2.0} ^2.1 Civantos FJ et al. Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: Results of a prospective multi-institutional trial. J Clin Oncol 2010 Mar 10; 28:1395. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20142602
↑ Wong SL, Faries MB, Kennedy EB, et al. Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update. Ann Surg Oncol. 2018 Feb;25(2):356-377. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29236202 https://www.ncbi.nlm.nih.gov/pubmed/29236202
↑ ^{Jump up to: 4.0} ^4.1 Reimer T et al. Axillary surgery in breast cancer - Primary results of the INSEMA trial. N Engl J Med 2024 Dec 12; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39665649 https://www.nejm.org/doi/10.1056/NEJMoa2412063
↑ Sentinel Lymph Node Biopsy: Questions and Answers National Cancer Institute http://www.cancer.gov/cancertopics/factsheet/therapy/sentinel-node-biopsy