scurvy; vitamin C deficiency
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Etiology
* case report of obese man with alcoholism & food restriction after bariatric surgery[2]
Clinical manifestations
- infantile form
- impaired bone growth
- irritability
- retrobulbar hemorrhage
- epistaxis
- hematuria
- purpura
- adult form
- petechiae, perifollicular petechiae
- congested hair follicles, perifollicular hemorrhage[4]
- ecchymoses (bruising)
- coiled hairs, corkscrew hairs
- gum changes
- gingival bleeding with loss of teeth[2]
- hyperkeratosis
- Sjogren's syndrome
- dyspnea
- arthralgia
- joint effusions
- femoral neuropathy
- edema
- weakness
- neuropathy
- leg pain (ache)
- orthostatic hypotension
- progressive fatigue, depression[4]
- rapid reversal of weakness with multivitamins[2]
Laboratory
- ascorbate in leukocytes (buffy coat)
- ascorbate in blood
- ascorbate in serum/plasma
- ascorbate in urine
- urine levels of little use
- serum sodium: hyponatremia[2]
- complete blood count: anemia (mild)
Differential diagnosis
Management
- vitamin C or multivitamin supplementation
More general terms
Additional terms
References
- ↑ Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
- ↑ Jump up to: 2.0 2.1 2.2 2.3 2.4 2.5 Bennett SE, Schmitt WP, Stanford FC, Baron JM. Case 22-2018: A 64-Year-Old Man with Progressive Leg Weakness, Recurrent Falls, and Anemia. N Engl J Med 2018; 379:282-289. July 19, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30021092 https://www.nejm.org/doi/full/10.1056/NEJMcpc1802826
- ↑ Jump up to: 3.0 3.1 Perkins A, Sontheimer C, Otjen JP, Shenoi S. Scurvy masquerading as juvenile idiopathic arthritis or vasculitis with elevated inflammatory markers: A case series. J Pediatr 2019 Dec 13; S0022-3476(19)31470-2 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31843213
- ↑ Jump up to: 4.0 4.1 4.2 Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022