AP-2 complex subunit alpha-2; adapter-related protein complex 2 alpha-2 subunit; adaptor protein complex AP-2 subunit alpha-2; alpha2-adaptin; plasma membrane adaptor HA2/AP2 adaptin alpha C subunit; alpha-adaptin C; clathrin assembly protein complex 2 alpha-C large chain; 100 kD coated vesicle protein C; Huntingtin-interacting protein J; Huntingtin yeast partner J (AP2A2, ADTAB, CLAPA, HYPJ, KIAA0899)

Function

• subunit of clathrin-associated adaptor protein complex 2 (HA2-AP2 adaptor complex)
• binds polyphosphoinositides (putative)
• binds EPN1, EPS15, AMPH, SNAP91 & BIN1 (putative)
• component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 & VIM

Structure

belongs to the adaptor complexes large subunit family

Compartment

• cell membrane, coated pit
• peripheral membrane, cytoplasmic side
• component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane

More general terms

• alpha adaptin
• phosphoprotein

Additional terms

• clathrin (triskelion)
• HA2/AP2 adaptor complex

Component of

• HA2/AP2 adaptor complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:161
• OMIM: https://mirror.omim.org/entry/607242
• UniProt: http://www.uniprot.org/uniprot/O94973.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=161