clathrin coat assembly protein AP180; clathrin coat-associated protein AP180; 91 kD synaptosomal-associated protein (SNAP91, KIAA0656)

Function

• adaptin
• binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (putative)
• binds AP2A2 (putative)
• phosphorylated (putative)

Structure

• 3 domain structure
  • N-terminal 300 residues harbor a clathrin binding site
  • acidic middle domain of 450 residues, interrupted by an Ala-rich segment
  • C-terminal domain (166 residues)
• contains 1 ENTH domain (epsin N-terminal homology)

Compartment

• cell membrane (putative)
• coated pit; peripheral membrane protein; cytoplasmic side
• component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane

Alternative splicing

named isoforms=3

More general terms

• adaptin
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9892
• OMIM: https://mirror.omim.org/entry/607923
• UniProt: http://www.uniprot.org/uniprot/O60641.html