clathrin interactor 1 (epsin-4, epsin-related protein, epsinR, enthoprotin, clathrin-interacting protein localized in the trans-Golgi region, Clint, CLINT1, ENTH, EPN4, EPNR, KIAA0171)
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Function
- binds to membranes enriched in phosphatidylinositol-4,5-bisphosphate
- transport via clathrin-coated vesicles from the trans-Golgi network to endosomes
- stimulates clathrin assembly
- binds clathrin heavy chain, GGA2, AP-2, AP1G1
Compartment
- cytoplasm, perinuclear region, peripheral membrane protein, clathrin-coated vesicle
- found throughout the cell, except the cell surface
- concentrated in the perinuclear region & associated with clathrin-coated vesicles close to trans-Golgi network
Alternative splicing
named isoforms=2
Expression
- ubiquitously expressed at low to intermediate levels