respiratory syncytial virus immune globulin

Indications

• prevention of lower respiratory tract infection caused by respiratory syncytial virus (RSV) in children < 24 months of age with bronchopulmonary dysplasia (BPD) or a history of premature birth (< 35 weeks gestation)

Contraindications

• selective IgA deficiency
• history of severe reaction to immune globulin

pregnancy-category C

safety in lactation ?

Dosage

• 750 mg/kg/month
  • 1.5 mL/kg/hr IV for 15 minutes
  • increase to 3 mg/kg/hr IV for another 15 minutes
  • 6 mL/kg/hr IV until completion of dose

IV administration only: 2500 mg RSV IgG/50 mL vial.

Pharmacokinetics

elimination: plasma

Adverse effects

• most common (1-10%)
  • rash, tachycardia, hypertension, hypotension, fever, fluid overload, vomiting, diarrhea, gastroenteritis, inflammation at injection site, respiratory distress, wheezing, rales, hypoxia, tachypnea
• uncommon (< 1%)
  • edema, pallor, heart murmur, cyanosis, flushing, palpitations, chest tightness, dizziness, anxiety, eczema, pruritus, abdominal cramps, myalgia, arthralgia, cough, rhinorrhea, dyspnea

More general terms

• immune globulin

Additional terms

• respiratory syncytial virus (RSV)