Lifestyle for Brain Health index (LIBRA)

Clinical significance

• higher LIBRA scores correlate with higher dementia risk

Procedure

LIBRA index includes

• modifiable dementia risk factors
  • physical inactivity
  • smoking
  • obesity
  • depression
  • diabetes mellitus type 2
  • chronic hypertension
  • hypercholesterolemia
  • chronic heart disease
  • chronic kidney disease
• protective factors
  • Mediterranean diet adherence
  • low to moderate alcohol use
• a 30 minute neuropsychological battery to measure cognitive performance,
  • memory
  • information processing
  • executive function
  • attention

Radiology

• brain MRI outcomes include
  • decreased gray matter volume*
  • white matter volume
  • increased CSF volume*
  • white matter hyperintensities*

* associated with higher LIBRA scores

Notes

• men had higher LIBRA scores than women

More general terms

• index