casirivimab/imdevimab (REGEN-COV)

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Indications

* reduces risk for hospitalization or death by ~70%.

* high risk criteria

Contraindications

Dosage

* dosage for adults & adolescents 12 years of age >= 40 kg

Storage

refrigeration, preservative free, discard vial within 4 hours of opening

Adverse effects

More general terms

Additional terms

Components

References

  1. Regeneron. Important Prescribing Information
  2. 2.0 2.1 FDA MedWatch program http://www.fda.gov/medwatch/report.htm
  3. Regeneron medical.information@regeneron.com
    Weinreich DM, Sivapalasingam S, Norton T et al REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19. N Engl J Med. 2021 Jan 21;384(3):238-251. Epub 2020 Dec 17. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33332778 Free PMC article
  4. 4.0 4.1 Walker M Monoclonal Antibody Cocktail Authorized for Post-COVID Exposure - REGEN-COV becomes first monoclonal antibody treatment with EUA following exposure alone. MedPage Today July 30, 2021 https://www.medpagetoday.com/infectiousdisease/covid19/93844
    O'Brien MP, Forleo-Neto E, Musser BJ et al Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19. N Engl J Med 2021. Aug 4 PMID: https://www.ncbi.nlm.nih.gov/pubmed/34347950 https://www.nejm.org/doi/full/10.1056/NEJMoa2109682
    O'Brien MP, Forleo-Neto E, Musser BJ Subcutaneous REGEN-COV Antibody Combination for Covid-19 Prevention.. medRxiv. 2021 Jun 17:2021.06.14.21258567. Preprint. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34159344 PMCID: PMC8219114 Free PMC article.
  5. 5.0 5.1 Frellick M Drug Cocktail Significantly Reduced Severe COVID, Death in Outpatients. Medscape. September 30, 2021 https://www.medscape.com/viewarticle/960060
    Weinreich DM, Sivapalasingam S, Norton T et al REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19. N Engl J Med. 2021 Dec 2;385(23):e81 PMID: https://www.ncbi.nlm.nih.gov/pubmed/34587383 Free PMC article. https://www.nejm.org/doi/full/10.1056/NEJMoa2108163
  6. Walker J Covid-19 Antibody Drugs Are Challenged by Omicron, Preliminary Testing Indicates. Regeneron said its antibody drug cocktail was found to lose effectiveness against the new variant. Wall Street Journal. November 30, 2021 https://www.wsj.com/articles/covid-19-antibody-drugs-are-challenged-by-omicron-preliminary-testing-indicates-11638270003
  7. 7.0 7.1 O'Brien MP, Forleo-Neto E, Sarkar N et al Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection. A Randomized Clinical Trial. JAMA. Published online January 14, 2022. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35029629 https://jamanetwork.com/journals/jama/fullarticle/2788256
  8. 8.0 8.1 American Medical Association (AMA) AMA Morning Rounds. Jan 25, 2022

Patient information

casirivimab/imdevimab (Regen-Cov) patient information