PRAME family member 9 (PRAMEF9)

Function

• substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase, which mediates ubiquitination of target proteins, leading to their degradation
• the CRL2(PRAMEF9) complex mediates ubiquitination & degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/sec decoding protein modification
• protein ubiquitination component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (elongin BC-CUL2/5-SOCS-box protein) complex, composed of UL2, elongin BC (ELOB & ELOC), RBX1 & substrate-specific adapter PRAMEF9

Structure

• belongs to the PRAME family,

More general terms

• PRAME family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=653619
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:653619
• UniProt: http://www.uniprot.org/uniprot/P0DUQ2.html