L-seryl-tRNA(sec) kinase; O-phosphoseryl-tRNA(sec) kinase (PSTK, C10orf89)

Function

• phosphorylates seryl-tRNA(Ser/Sec) to yield O-phosphoseryl- tRNA (Ser/Sec), an activated intermediate for selenocysteine biosynthesis (putative)
• aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(sec) biosynthesis; selenocysteinyl-tRNA(sec) from L-seryl-tRNA(sec) (archaeal/eukaryal route): step 1/2

Cofactor: Mg+2 (putative)

Structure

belongs to the L-seryl-tRNA(sec) kinase family

Alternative splicing

named isoforms=2

More general terms

• kinase or ATP-phosphotransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=118672
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:118672
• OMIM: https://mirror.omim.org/entry/611310
• UniProt: http://www.uniprot.org/uniprot/Q8IV42.html