O-phosphoseryl-tRNA(sec) selenium transferase (selenocysteine synthase, Sec synthase, selenocysteinyl-tRNA(Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS, UGA suppressor tRNA-associated protein, tRNA(ser/Sec)-associated antigenic protein, SLA/LP autoantigen, soluble liver antigen, SLA, Liver-pancreas antigen, LP, SLA-p35, SEPSECS, TRNP48)

Function

• converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis
• aminoacyl-tRNA biosynthesis, selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2

Cofactor: pyridoxal phosphate

Structure

belongs to the SepSecS family

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• primarily expressed in liver, pancreas, kidney & lung
• overexpressed in PHA-stimulated T-cells

Pathology

• possible diagnostic marker for autoimmune hepatitis

More general terms

• transferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9HD40.html